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On June 22, 2007, the FDA issued the Dietary Supplements Final Rule to ensure the strength of dietary supplements and the absence of harmful contaminants in the products.

In a letter dated February 25, 2005, Dr. Lee asked the FDA to set a standard for the green tea that is used by the consumers for health protection. The NCI standard for green tea leaves is 7.1% EGCG. The tea leaves for health protection should be free of pesticides. The maximum allowable residual lead in the tea leaves should not exceed 5 ppm. Fluoride levels in bottled tea should not exceed 2.4 ppm to avoid tea fluorosis, as set by the FDA for other bottled beverages.

The FDA has recently approved green tea extracts as a topical drug to treat human papillomavirus (HPV)-induced external genital condylomatous lesions, for the first time affirming the antiviral activity of green tea if the right dose is delivered to a lesion. Green tea components have been shown to have an antiviral effect against many viruses, including the AIDS virus.

About 4 years ago, a group of scientists reported that appropriate green tea products administered at the right dosage orally or topically are effective in reversing the progression of HPV-infected uterine cervical lesions, which may lead to cancer. Interested readers may read the report about the protective effects of green tea extracts on human cervical lesions. The above FDA decision and the report show that HPV-induced lesions may be reversible when proper green tea products are administered. Green tea may be protective against the HPV infections for which the type-specific Gardasil® HPV vaccines are not effective. Dr. Sin Hang Lee and his colleagues have developed an accurate genotyping test to monitor HPV infections before and after immunization to develop prevention strategy for the individual patients. Interested readers may read Dr. Lee’s recently published scientific report on routine HPV genotyping by DNA sequencing and consult their physicians on the importance of accurate HPV genotyping in non-surgical management of HPV infections.
Gardasil® is a registered trademark of Merck & Co., Inc.

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